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Gentest® Antibody-Drug Conjugate (ADC) Off-Target Toxicity and Linker Stability Services

Evaluate ADC off-target toxicity and ADC linker stability quicky and cost-effectively.

Discovery’s off-target toxicity and linker stability assays help you predict two distinct issues with antibody-drug conjugate (ADC) therapeutics.

Using modified colony-forming cell (CFC) assays, we evaluate your ADC candidates for potential hematotoxicity concerns, including neutropenia and thrombocytopenia. Our experts can assess the stability of your ADC’s linker in the presence of neutrophils, which are known to cause their own demise by releasing enzymes that cleave the drug payload from the ADC.

Gentest® Off-Target Toxicity Service

Gentest® Linker Stability Service

Featured Resources

ADC Off Target Tox and Linker Stability

White Paper

Colony Forming Cell Assays Predict Compound Induced Toxicities

Colony Forming Cell assays can predict compound induced toxicities including neutropenia, thrombocytopenia, anemia and lymphotoxicity. Video

DB-ALM Protocol n° 101

The haematotoxic potential of xenobiotics is determined by the evaluation of the inhibition of CFU-GM growth. White Paper

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