Find Out Why Pre‑Sequenced Biospecimens Matter More Than Ever. Validated Genomics Assays for Clinical Trials Step into the Future of Liver Science in 3D. Real World Applications of SpecimenSeq.
Find Out Why Pre‑Sequenced Biospecimens Matter More Than Ever. Validated Genomics Assays for Clinical Trials Step into the Future of Liver Science in 3D. Real World Applications of SpecimenSeq.
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Expression patterns in tissue at any stage of development.

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Discovery’s High Quality IHC and Histopathology Services

Helping you understand your target biomarkers at every stage of research and clinical development using any leading technology platform-

DAKO, VENTANA, LEICA & TECHMATE

Understand Biomarkers & Indications

  • Discuss study goals and timelines with sponsor
  • Understand mechanism of action and targeted biomarkers of interest
  • Determine appropriate controls, i.e. cell lines, xenografts, animal and human control tissues
  • Determine tumor indications of interest – if unclear, survey many indications
  • Select biospecimens with specific characteristics, e.g. metastatic, morphologic distinction, etc.
  • Determine the best commercially available primary antibodies for targets of interest
  • Identify novel antibodies and screen clones from internal antibody campaigns

Optimize Biomarker Assay

  • Test & select optimal pretreatment conditions
  • Determine assay specificity
  • Test range and linearity for assay robustness
  • Screen tissue and test sensitivity
  • Develop scoring scheme
  • Validate precision & reproducibility
  • Adhere to applicable GCLP guidelines
  • Deliver IND submission-ready analytical reports

Utilize Biomarker Assay

  • Conduct IHC testing of research or clinical samples – retrospective or prospective studies
  • Determine assay specificity
  • Provide full-service histology and ASCP certified pathology analysis
  • Determine expression across tumor indications (Tumor Survey)
  • Set cut-off for positivity for patient sample screening and enrollment (CAP/CLIA)
  • Develop Prototype CDx: strategy for testing & downstream commercialization
  • Deliver customized reporting & data transfer
  • Adhere to GCLP and CLIA guidelines

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