SpecimenSeq^TM
NGS-Characterized Biospecimens

NGS-characterized biospecimens are tissue or cell samples that have been pre-analyzed using next-generation sequencing to identify mutations, gene expression profiles, and other genomic features. This provides researchers with data-rich samples that reduce time and cost in oncology, immunology, and biomarker validation studies. Discovery's SpecimenSeq™ technology delivers this NGS characterization with consistency and high analytical rigor.

Pre-sequenced biospecimens help oncology researchers quickly identify relevant mutations, validate therapeutic targets, and build genetically defined cohorts. With gene panel data already available, these samples accelerate hypothesis testing and drug stratification strategies.

SpecimenSeq™ products include FFPE blocks, frozen tissue, dissociated tumor cells (DTCs), matched sets (e.g., PBMC + tumor), and biofluids, each pre-sequenced across thousands of clinically relevant genes. See available sample types here.

Discovery’s SpecimenSeq™ biospecimens are characterized using targeted NGS panels covering clinically relevant genes for oncology, immunology, and rare disease indications across 1,200+ genes, including fusions, CNVs, SNVs, TMB, and MSI.

Matched biospecimen sets are created by collecting different sample types (e.g., tumor tissue and pre-surgery blood draws) from the same donor. This allows researchers to correlate genomic, transcriptomic, and immunologic data for deeper insights into disease biology or therapeutic response.

Matched set inventory includes FFPE + Double-spun plasma (DSP) + buffy coat (non-viably frozen) sets for the purpose of extracting and comparing tumor DNA (FFPE), circulating tumor DNA (DSP), and germline DNA (buffy coat) to support liquid biopsy research for disease monitoring and early detection. Pre-surgery whole blood is collected either in EDTA tubes that are processed within 2 hours or Streck tubes processed within 48 hours.

Both products capture the same cells, the buffy layer of peripheral blood. Discovery’s buffy coat inventory is collected during our double-spun plasma processing and is non-viably frozen for the purpose of a genomic germline control. Discovery’s PBMC inventory is viably cryopreserved for end uses such as cell culture or co-culture, flow cytometry, or single cell genomics.

Yes. Most SpecimenSeq™ samples include key clinical metadata such as diagnosis, indication, treatment history (if applicable), and pathology reports. Custom fields may be available upon request.

Turnaround time for SpecimenSeq™ biospecimens depends on sample type and customization needs. For in-stock, pre-characterized tissues, samples can typically ship in 1–2 weeks. Custom-matched or freshly procured sets may take 3–6 weeks.

Yes, if your target isn’t already sequenced, Discovery can generate additional NGS panels in our Genomics Service Lab. Discuss your custom characterization needs with our biospecimen specialist.