Discovery’s cell biologists utilize Luminex, IsoPlexis, and ELISA to deliver highly sensitive immune profiling, enabling precise quantification of cytokine expression and accelerating drug development through informed target validation, therapeutic efficacy assessment, and immune-related toxicity monitoring.
Multiplex cytokine analysis offers high sensitivity and specificity, enabling the simultaneous detection of multiple cytokines in a single sample. Using advanced platforms like Luminex™ xMAP™ INTELLIFLEX and IsoSpark, our cell biologists deliver precise, quantitative measurements across a broad range of cytokines, accelerating data collection for various diseases and conditions.
ELISA-based cytokine and antibody analysis offers high sensitivity and specificity, enabling the accurate detection of low-abundance cytokines and antibodies with minimal cross-reactivity. This single-plex assay provides precise, quantitative measurements, making it ideal for clinical diagnostics .
We support a wide range of applications, including biomarker discovery, immune response profiling, therapeutic efficacy assessment, inflammatory disease monitoring, and cancer immunotherapy evaluation
Our cell biologists can perform T cell activation and cytokine release assays to predict a therapeutic’s risk of causing cytokine release syndrome (CRS) before clinical trials.
There is significant variability in cytokine secretion between donors, so we typically would suggest a minimum of 3 donors. For more information, please schedule a consultation with us.
We can test soluble, wet-bound, or air-dried presentation of the antibody in wells of a 96 well-plate.
We use Dynabeads to confirm stimulation of blood cells and cytokine release and we use Crisaborole as a control to reduce cytokine release.
