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Cytokine Analysis Services

Discovery’s cell biologists utilize Luminex, IsoPlexis, and ELISA to deliver highly sensitive immune profiling, enabling precise quantification of cytokine expression and accelerating drug development through informed target validation, therapeutic efficacy assessment, and immune-related toxicity monitoring.

Expert Cell Biology. High-Quality Libraries. Unmatched Single Cell Insights.

Multiplex cytokine analysis offers high sensitivity and specificity, enabling the simultaneous detection of multiple cytokines in a single sample. Using advanced platforms like Luminex™ xMAP™ INTELLIFLEX and IsoSpark, our cell biologists deliver precise, quantitative measurements across a broad range of cytokines, accelerating data collection for various diseases and conditions.

Luminex™ xMAP™ INTELLIFLEX Cytokine Analysis

1 to 80 analytes per sample
40 samples per run
Reduced input sample volume
Robust signal detection with minimal sample loss

IsoSpark IsoPlex Cytokine Analysis

About 30 analytes per sample
4 samples per run
Single-cell profiling with deep immune insights
Real-time immune monitoring with high sensitivity and resolution

Precision ELISA-Based Cytokine Analysis

Fast, Reliable, and Versatile

ELISA-based cytokine and antibody analysis offers high sensitivity and specificity, enabling the accurate detection of low-abundance cytokines and antibodies with minimal cross-reactivity. This single-plex assay provides precise, quantitative measurements, making it ideal for clinical diagnostics .

We support a wide range of applications, including biomarker discovery, immune response profiling, therapeutic efficacy assessment, inflammatory disease monitoring, and cancer immunotherapy evaluation

T Cell Activation and Cytokine Release Assay

Fast, Reliable, and Versatile.

Our cell biologists can perform T cell activation and cytokine release assays to predict a therapeutic’s risk of causing cytokine release syndrome (CRS) before clinical trials.

Assess T cell activation and cytokine release potential of drug candidates
Evaluate efficacy of therapies aimed at restricting cytokine secretion
Analyze antibody-based drugs, small molecules, and CAR-T cells
Adapt assays for allergy and inflammatory drug evaluations
Compare drug candidates with commercial therapies known for stimulatory or inhibitory effects

Frequently Asked Questions

How many donors should we assess for cytokine release?

There is significant variability in cytokine secretion between donors, so we typically would suggest a minimum of 3 donors. For more information, please schedule a consultation with us.

What are the typical antibody presentations you test?

We can test soluble, wet-bound, or air-dried presentation of the antibody in wells of a 96 well-plate.

What controls do you use?

We use Dynabeads to confirm stimulation of blood cells and cytokine release and we use Crisaborole as a control to reduce cytokine release.

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Cytokine Analysis Services

Expert Cell Biology. High-Quality Libraries. Unmatched Single Cell Insights.

Luminex™ xMAP™ INTELLIFLEX Cytokine Analysis

IsoSpark IsoPlex Cytokine Analysis

Precision ELISA-Based Cytokine Analysis

Fast, Reliable, and Versatile

T Cell Activation and Cytokine Release Assay

Fast, Reliable, and Versatile.

Frequently Asked Questions

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