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Immunohistochemistry
(IHC) Services

Expression patterns in tissue at any stage of development.

Rely on Discovery's Experts to Expedite Your IHC Projects

Our IHC services are provide by the scientists who help develop the low HER2 and PDL1 CDx assays. We give precise and impactful insights into biomarker development, therapeutic target validation and prevalence, from preclinical to CDx development

Expertise

Decades of experience developing, validating and applying biomarker assays throughout every stage of development for leading biotech and pharma clients.

Technology

A technology agnostic approach to enable an unbiased selection of the most suitable platforms.

Compliance & Quality

Specialty testing in CLIA-certified, CAP accredited, and GCLP compliant service laboratories to support concurrent clinical trials and regulatory submissions.
IVDR-compliant services with Health Institution status of Discovery’s laboratory in Germany confirmed by German Regional Council.

Global Harmonization

Global standardization and harmonization of assays including global clinical trial testing and our Biomarker Academy™ training programs with post-approval services.

Access to Clinical Specimens

Access to the world’s largest commercial biorepository to build optimal study cohorts.

Rapid Orthogonal Testing

Optimized multi-omic integration with clinical flow, cell biology, genomic, and proteomic services – all under one roof.

Discovery’s Immunohistochemistry Services

Our experts have designed an industry-leading assay validation approach that starts with careful assay development and optimization. We do more than simply demonstrate that an assay can detect a target in various conditions, we:

Conduct large scale sensitivity screening of cancer patient populations to understand expression patterns within and among tumor indications
Demonstrate precision and reproducibility using serial sections from samples with various levels of known target expression
Analyze specificity in cell lines, xenografts, and normal human tissues
Develop a robust scoring scheme to properly and consistently the capture level of target expression
Analyze expression rate for cut-off determination in various disease indications
CLIA-certified, CAP-accredited, and GCLP compliant laboratories in Europe and the US

Technology Platforms

We use a technology agnostic approach so you can choose the right technology for your project. Our expert scientists work with you consultatively to make sure your study is designed to achieve optimal outcomes.

Digital Pathology / Scanners / Image Analysis

ICH / Multiplex IF /
ISH

Applications

Detect biomarkers across a broad range of normal and diseased tissue
Classify diseases and identify unique patient cohorts
Validate therapeutic targets
Assess drug efficacy and mechanism of action
Testing of retrospective and prospective (CAP/CLIA) clinical trial patient samples
Develop CDx programs faster with CAP/CLIA and IVDR compliance (note: Discovery’s Health Institution status of Kassel, Germany laboratory)
Understand targets in preclinical models and accelerate transition to the next stage of development

Contact Us Today

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Latest Updates:

Announcement:

Immunohistochemistry(IHC) Services

Rely on Discovery's Experts to Expedite Your IHC Projects

Expertise

Technology

Compliance & Quality

Specialty testing in CLIA-certified, CAP accredited, and GCLP compliant service laboratories to support concurrent clinical trials and regulatory submissions. IVDR-compliant services with Health Institution status of Discovery’s laboratory in Germany confirmed by German Regional Council.

Global Harmonization

Access to Clinical Specimens

Rapid Orthogonal Testing

Optimized multi-omic integration with clinical flow, cell biology, genomic, and proteomic services – all under one roof.

Discovery’s Immunohistochemistry Services​

Technology Platforms

Digital Pathology / Scanners / Image Analysis

ICH / Multiplex IF / ISH

Applications

Contact Us Today

November 2024

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