A novel in vitro assay that incorporates hepatic metabolism into hematopoietic toxicity evaluation, addressing a critical gap that standard CFC assays overlook.
By co-culturing pooled hepatocytes and CD34+ cells with novel pharmaceuticals, we can evaluate possible metabolism-dependent toxicity by measuring the clonogenic potential of CD34+ cells in a Colony Forming Cell (CFC) assay. Colony enumeration is executed by experts to ensure accurate and reliable results.
High-quality, assay-ready Gentest® Cryopreserved Pooled Hepatocytes are used in this assay for better consistency, reproducibility, and faster time-to-results.
Incorporation of Hepatic Metabolism in the Hematopoietic Stem Cells (HSC) Toxicity Assay via Co-Culturing of HSC with Primary Human HepatocytesAbstracts & Posters
