Inhibition of drug metabolizing enzyme catalytic activity is a leading mechanism of drug-drug interactions. In vitro enzyme inhibition studies are valuable tools to predict the clinical drug-drug interaction potential of NCEs.
Gentest® Research Services utilizes pooled human liver microsomes (UltraPool HLM150 ) as well as cDNA expressed individual enzymes (Supersomes™) to deliver robust, reproducible results. The combination of proprietary products, regulatory guidance driven protocols and highly experienced study directors provides clients with reliable, submission-ready results.
