Inhibition and induction of drug metabolizing enzyme catalytic activity is a leading mechanism of drug-drug interactions. In-vitro reaction phenotyping studies elucidate the metabolic pathways of new chemical entity (NCE) and help identify the drug’s vulnerabilities to drug-drug interactions. Gentest® Research Services are customized around each NCE’s ADME profile and utilize multiple different test systems to ensure robust, reproducible results. The combination of proprietary products, regulatory guidance driven protocols, and highly experienced study directors provides clients with reliable, submission-ready results.
