ATP-binding cassette (ABC) and solute carrier (SLC) transporter proteins can influence absorption and elimination of xenobiotics across the cell membrane and may be major determinants of the pharmacokinetic profiles of drugs. In vitro transporter studies are valuable predictors of in vivo drug-drug interactions and the magnitude of that interaction.

Gentest® ADMET Research Services utilizes high quality, highly characterized cell lines and transporter products to deliver robust, reproducible results. The combination of proprietary products, regulatory guidance driven protocols, and highly experienced study directors provides clients with reliable, submission-ready results.