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Gentest® Supersomes

Analyze ADME drug properties with the industry
gold standard Cytochrome P450 (CYP) recombinant enzymes

Gentest® Supersomes are the gold standard for ADME studies, containing the highest quality recombinant Cytochrome P450 (CYP) enzymes.

These enzymes are prepared from baculovirus-transfected insect cells with very high levels of catalytic activities
(typically 6-fold higher than an average human liver microsome sample).

Supersomes are ideal for study of high throughput drug interactions, slowly metabolized chemicals, or large-scale production of metabolites for structural identification.

Figure 1. Typical time course for Gentest Supersomes P450 enzymes. Linear time is >50 minutes.

Table 1. Enzyme kinetics between Gentest Supersomes enzymes and liver microsomes (HLM) show excellent consistency.

Figure 2. Comparison of Supersomes enzyme activities and HLM activities.

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