Cytochrome P450 & UGT and oxidase & esterase inhibition studies to predict drug-drug interaction.
Understanding how a drug candidate is metabolized, transported, and cleared is an essential part of the drug development process. Discovery Life Sciences’ (Discovery’s) Gentest® ADME & Custom Services have provided IND-enabling in vitro ADME and bioanalytical services for more than two decades, helping countless drug developers get the answers they needed to make critical go/no-go decisions.
Differential time- and NADPH-dependent inhibition of CYP2C19 by enantiomers of fluoxetine
Highly selective inhibition of human CYP3Aa in vitro by azamulin and evidence that inhibition is irreversible
Predictive In Vitro-In Vivo Extrapolation for Time Dependent Inhibition of CYP1A2, CYP2C8, CYP2C9, CYP2C19, and CYP2D6 Using Pooled Human Hepatocytes, Human Liver Microsomes, and a Simple Mechanistic Static Model
