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Gentest®
Tissue Fraction Products

Conduct IND-enabling drug metabolism studies with specialized subcellular tissue fractions.

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Gentest’s high quality, specialized tissue fractions expand beyond human liver microsomes (HLMs) to include other liver fractions (cytosol and S9), intestinal tissue fractions, and animal tissue fractions.

  • Human Liver Microsomes UltraPoolTM HLM 150
  • Cytosol: Contains soluble phase II enzymes; GST, NAT, and SULT
  • S9: Contains both phase I and II enzymes, liver microsomes and cytosol fractions
  • Mixed Pooled Human Intestinal Microsomes
  • Prepared from both the duodenum and jejunum sections of the small intestine
  • Suitable for intestinal metabolism testing of CYP2C9, 3A4, 2J2/4F12, UGT1A, and carboxylesterase
  • Animal Tissue Fractions
  • Ensured availability via large production lots
  • Pooled donors minimize lot-to lot variability
  • Characterized for total P450, Cytochrome b5, Oxidoreductase (OR), CYP3A, CYP2C, CYP2E1, CYP1A, and CYP4A
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Overview of the manufacturing workflow

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Gentest® Human Liver Microsomes (HLM)
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Join Discovery Life Sciences at ISCT 2024 Stop by our booth #453 or schedule a meeting with our CGT team. May 28- 31, 2024 | Vancouver, Canada

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