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Gentest^®
Human Liver Microsomes

A rich, convenient, and cost-effective source of native enzymes
responsible for drug metabolism studies.

Discovery's Gentest^® Human Liver Microsomes are a great source of native enzymes responsible for drug metabolism, including cytochrome P450 (CYP), UDP-glucuronosyl transferase (UGT), and flavin-containing monooxygenase (FMO).

They are ideal for metabolic stability, metabolite reactivity, drug-drug interactions, reaction phenotyping, and metabolite identification studies. Gentest^® HLMs adhere to the highest safety standards, undergo rigorous serological and PCR testing, and offer a variety of options including single-donor, mixed, and specialty pools.

Gentest^® UltraPool™ HLM 150 is the first commercially available large donor pool of HLMs (~150 donors) that naturally represents the average patient population and known CYP polymorphisms. This unique product offers consistency and large lot sizes, enabling multi-year studies. UltraPool^TMis also fully characterized according to GLP standards for major CYP activities and select phase II enzymes using FDA-recommended substrates.

Ensures CYP polymorphism population representation with a 150-donor pool
Enables consistent experimental results in multi-year programs
Saves time and expense by eliminating the need to qualify new HLM lots
Assists IND filing with full characterization consistent with GLP standards for major CYP activities and select phase II enzymes using FDA-recommended substrates
Facilitates reproducibility with large lots characterized for a range of important CYP, FMO, and UGT enzymes

Discovery also provides a range of other microsome products, including 20- and 50-donor products, as well as mixed or single gender options.

20- and 50- donor pooled HLMs
Pooled single gender HLMs formulated from five or more donors
Mixed pooled cytomegalovirus (CMV) negative HMLs formulated from male and female donors
Mixed pooled human intestinal microsomes (duodenum and jejunum) for intestinal metabolism testing of CYP2C9, 3A4, 212/F12, UGT1A, and carboxylesterase
High/low catalytic activity P450 single donor HLMs
Genotyped allelic variant HLMs

Gentest®Human Liver Microsomes

Discovery's Gentest® Human Liver Microsomes are a great source of native enzymes responsible for drug metabolism, including cytochrome P450 (CYP), UDP-glucuronosyl transferase (UGT), and flavin-containing monooxygenase (FMO).

Explore Related Gentest® ADME Research Services

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May 2024

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Gentest^®
Human Liver Microsomes

Discovery's Gentest^® Human Liver Microsomes are a great source of native enzymes responsible for drug metabolism, including cytochrome P450 (CYP), UDP-glucuronosyl transferase (UGT), and flavin-containing monooxygenase (FMO).

Explore Related Gentest^® ADME Research Services

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