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Gentest® In Vitro
Preclinical Services

Innovative In vitro laboratory services to accelerate drug development.

Gentest® In Vitro Preclinical Services is your flexible, accessible partner in preclinical research

We go beyond protocol execution, offering direct collaboration with our experienced scientists who can design studies specifically tailored to ensure meaningful, clinically relevant data on your drug candidates. We help you bring your therapeutics to the clinic faster with our IND-enabling hematotoxicity assays and Gentest® ADME services. Additionally, a range of blood cell-based assay services enables you to study both drug efficacy and deleterious drug impacts.

Gentest® ADME Research Services

Enabling IND submissions for over 20 years, our team of ADME experts can design studies to predict your drug candidate’s drug-drug interactions and pharmacokinetics. Studies are aligned with the most current regulatory guidance (e.g., FDA, EMA, and ICH). Gentest ADME Research Services rely on our trusted Gentest in vitro products and cell models. 

Hematopoietic Colony Forming Cell (CFC) Assay Services

Predict neutropenia, severe anemia, and thrombocytopenia caused by your drug candidate’s off-target toxicity to hematopoietic progenitor cells with our in vitro, IND-enabling, CFC assay services. We use primary cells and growth factors for lineage-specific cell differentiation to replicate the in vivo environment versus cell line-based studies. With decades of experience performing CFC assays, we can assist you with fit-for-purpose study design.

Additional Blood Cell-Based Assay Services

We understand in vitro blood cell culture systems at a deep level, whether it is the fastidious conditions required for bone marrow progenitor cell differentiation or the complexities of interactions between mature blood cells and stimulants or targets. We can study your drug candidate’s efficacy or deleterious impact potential in a variety of blood cell-based assays. We also welcome the opportunity to work with you on customized assays or the replication of published protocols, including immuno-oncology studies.

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