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Gentest^® TransportoCells™

Conduct transporter interaction studies faster with Discovery’s solute carrier (SLC) transporter expressing cells and ATP-binding cassette (ABC) transporter vesicles

Gentest TransportoCells™ products are high-performance mammalian cells in a convenient, cryopreserved format that transiently overexpress a single human SLC transporter protein. These frozen cells deliver robust data, while eliminating the time required to culture and maintain stable cell lines.

Speed: Cryopreserved and ready for use immediately after thawing (transporter vesicles) or within 24 hours (transporter expressing cells)
Cost-efficiency: TransportoCells™ eliminate the need to maintain stable cell lines
Scale: designed for high throughput screening in ADME studies
Accuracy: More predictive of mammalian in vivo activity than most other recombinant models
Trust: TransportoCells™ are used in our IND-enabling Gentest® ADME Research Services
Validated LC-MS/MS analysis for most enzymes (HPLC for CYP4A11, spectrophotometry for ChE)

Options: Transporter-qualified primary hepatocytes are also available for suspension or monolayer assays

Gentest^® Cryopreserved Solute Carrier (SLC) TransportoCells™

Solute carrier (SLC) transporters are membrane proteins involved in drug disposition, and they are responsible for the transport of endogenous and exogenous compounds across biological membranes, making them the ideal model for ADME studies.

Offer convenience with single-use HEK-293 cells expressing a single transporter
Cryopreserved cells can be thawed, plated, and ready to use in under 24 hours
Directly measure transporter-mediated drug uptake
Provide high, robust signal-to-noise ratio (S:N ≥ 10)
Assay drug uptake for radiolabeled or non-radiolabeled compounds

Gentest^® TransportoCells™ HEK-293-Derived ABC Transporter Vesicles

Improve the predictive potential of your transporter drug-drug interaction, reaction phenotyping, and toxicity studies with a validated, more human-like transporter-protein expressing vesicle model.

Provide more in vivo-like recombinant proteins and membrane composition
Demonstrate a robust dynamic range with higher uptake activity and lower background than insect expression systems
Cryopreserved and ready for immediate use after thawing in a water bath
Validated for substrate specificity, transporter kinetics, and inhibition profiles
Support FDA, EMA, and ITC recommendations for identifying drug transporters and studying transporter drug-drug interaction

Gentest^® Transporter Kits

Transporter membrane and vesicle kits reduce the time needed to prepare reagents. The ATPase kit contains the required buffers and chemicals for performing five 96-well microplate assays. The BSEP and BCRP/MRP kits contain all necessary buffers and chemicals for performing 200 assays.

Note: Kits do not contain vesicle or membrane preps.

Gentest® TransportoCells™

Gentest® Cryopreserved Solute Carrier (SLC) TransportoCells™

Gentest® TransportoCells™ HEK-293-Derived ABC Transporter Vesicles

Gentest® Transporter Kits

Explore Related Gentest® ADME Research Services:​

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May 2024

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Gentest^® TransportoCells™

Gentest^® Cryopreserved Solute Carrier (SLC) TransportoCells™

Gentest^® TransportoCells™ HEK-293-Derived ABC Transporter Vesicles

Gentest^® Transporter Kits

Explore Related Gentest^® ADME Research Services:

Development and Clinical
Trial Solutions

Development and Clinical
Trial Solutions