What is the difference between PBMCs and MNCs?

At Discovery Life Sciences, peripheral blood mononuclear cells (PBMCs) notates cells isolated from whole blood, while mononuclear cells (MNCs) represent cells isolated from apheresis material. During the apheresis process, granulocytes, red blood cells, and platelets are reduced in the specimen, and are further removed during the processing. Therefore, MNCs will have drastically reduced levels of platelets compared to whole blood PBMCs.