A rich, convenient, and cost-effective source of native enzymes responsible for drug metabolism studies.
They are ideal for metabolic stability, metabolite reactivity, drug-drug interactions, reaction phenotyping, and metabolite identification studies. Gentest® HLMs adhere to the highest safety standards, undergo rigorous serological and PCR testing, and offer a variety of options including single-donor, mixed, and specialty pools.
Gentest® UltraPool™ HLM 150 is the first commercially available large donor pool of HLMs (~150 donors) that naturally represents the average patient population and known CYP polymorphisms. This unique product offers consistency and large lot sizes, enabling multi-year studies. UltraPoolTM is also fully characterized according to GLP standards for major CYP activities and select phase II enzymes using FDA-recommended substrates.
Discovery also offers mixed pooled human intestinal microsomes (duodenum and jejunum) for intestinal metabolism testing of CYP2C9, 3A4, 212/F12, UGT1A, and carboxylesterase.
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