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Gentest^® Supersomes^®

Analyze ADME drug properties with the industry
gold standard Cytochrome P450 (CYP) recombinant enzymes

Gentest^® Supersomes^® are the gold standard for ADME studies, containing the highest quality recombinant Cytochrome P450 (CYP) enzymes.

These enzymes are prepared from baculovirus-transfected insect cells with very high levels of catalytic activities
(typically 6-fold higher than an average human liver microsome sample).

Supersomes are ideal for study of high throughput drug interactions, slowly metabolized chemicals, or large-scale production of metabolites for structural identification.

Provide the most comprehensive set of CYP enzymes
Facilitate efficient metabolite formation with long linear time course, ideal for slow metabolizing drug compounds (Figure 1)
Deliver high-catalytic activity for robust high throughput drug-drug interaction screening assays (Figure 2)
Ensure similar enzyme kinetics to native enzymes expressed in human liver and other organs (Table 1)
Support FDA new drug registration assay requirements such as reaction phenotyping and enzyme inhibition
Enable evaluation of pro-drugs and CYP pathway of elimination in pharmacokinetic studies
Used in Gentest’s IND-enabling ADME research services

Figure 1. Typical time course for Gentest Supersomes P450 enzymes. Linear time is >50 minutes.

Table 1. Enzyme kinetics between Gentest Supersomes enzymes and liver microsomes (HLM) show excellent consistency.

Figure 2. Comparison of Supersomes enzyme activities and HLM activities.

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Gentest® Supersomes®

Gentest® Supersomes® are the gold standard for ADME studies, containing the highest quality recombinant Cytochrome P450 (CYP) enzymes.

Supersomes are ideal for study of high throughput drug interactions, slowly metabolized chemicals, or large-scale production of metabolites for structural identification.

Gentest Technical Resources

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Gentest^® Supersomes^®

Gentest^® Supersomes^® are the gold standard for ADME studies, containing the highest quality recombinant Cytochrome P450 (CYP) enzymes.

Development and Clinical
Trial Solutions

Development and Clinical
Trial Solutions