Project Flow

Expression patterns in tissue at any stage of development.

Discovery’s High Quality IHC and Histopathology Services

Helping you understand your target biomarkers at every stage of research and clinical development using any leading technology platform-

Discuss study goals and timelines with sponsor
Understand mechanism of action and targeted biomarkers of interest
Determine appropriate controls, i.e. cell lines, xenografts, animal and human control tissues
Determine tumor indications of interest – if unclear, survey many indications
Select biospecimens with specific characteristics, e.g. metastatic, morphologic distinction, etc.
Determine the best commercially available primary antibodies for targets of interest
Identify novel antibodies and screen clones from internal antibody campaigns

Conduct IHC testing of research or clinical samples – retrospective or prospective studies
Determine assay specificity
Provide full-service histology and ASCP certified pathology analysis
Determine expression across tumor indications (Tumor Survey)
Set cut-off for positivity for patient sample screening and enrollment (CAP/CLIA)
Develop Prototype CDx: strategy for testing & downstream commercialization
Deliver customized reporting & data transfer
Adhere to GCLP and CLIA guidelines