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Gentest^®
Transporter Interaction Services

Gentest^® ADMET Research Services’ in vitro studies are valuable predictors of the existence and magnitude of in vivo drug-drug interactions

ATP-binding cassette (ABC) and solute carrier (SLC) transporter proteins can influence absorption and elimination of xenobiotics across the cell membrane and may be major determinants of the pharmacokinetic profiles of drugs.

Discovery has been providing expert, regulatory submission-quality ADME services for more than two decades, and we utilize the high-performance Gentest TransportoCells™ in our transporter interaction services.

Performed with a Comprehensive Portfolio of Clinically Relevant Transporters

Our Advanced Cellular Models & Membrane Vesicles Lead the Way

Gentest^® MDR1-LLC-PK1 cell model, consisting of an over-expressing human P-gp (MDR1) cell line and a vector-control cell line.

Where Expert Guidance Meets Gold Standard Reagents

Gold standard, highly characterized Gentest^® reagents are used whenever possible and guarantee reproducible results
Expert study directors ensure your studies are designed in alignment with FDA and EMA regulatory guidance
Transporter phenotyping and inhibition (IC₅₀) assays conducted using regulatory agency recommended, transporter-specific substrates and inhibitors
Typical transporter phenotyping study tests 3 concentrations of test article in absence and presence of known inhibitor(s).
IC₅₀ study design uses triplicate incubations with 7 non-zero concentrations of the test article
In vitro IC₅₀ data used to perform risk assessment of in vivo transporter inhibition based on regulatory agency guidance (e.g., ratio/cut-off values)
High quality submission-ready data and study report

Gentest®Transporter Interaction Services

ATP-binding cassette (ABC) and solute carrier (SLC) transporter proteins can influence absorption and elimination of xenobiotics across the cell membrane and may be major determinants of the pharmacokinetic profiles of drugs.

Performed with a Comprehensive Portfolio of Clinically Relevant Transporters

Our Advanced Cellular Models & Membrane Vesicles Lead the Way

Where Expert Guidance Meets Gold Standard Reagents

Adaptable, Customizable Transporter Interaction Studies

Contact Us Today

May 2024

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Gentest^®
Transporter Interaction Services

Development and Clinical
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Development and Clinical
Trial Solutions